The in-vitro immunomodulatory activity of Bauhinia variegata Linn (Caesalpiniaceae) stem bark extracts on human neutrophils was carried out in the present study. The acetone-water, aqueous extracts and isolated compound (tannin) of Bauhinia variegata stem bark were screened for their possible immunomodulatory activity by assessing nitroblue tetrazolium test, phagocytosis of killed Candida albicans, candidacidal assay, neutrophil locomotion and chemotaxis. All the extracts were tested at concentrations viz. 10 mg/ml, 20 mg/ml, 50 mg/ml, 100 mg/ml and 1000 mg/ml. The acetone:water and isolated compound of Bauhinia variegata Linn stem bark showed predominantly significant activity on in vitro human neutrophils in all parameters, which are comparable to standard and control at different concentration indicating the possible immunostimulating effect.